How scientists want to make you young again – MIT Technology Review

For now, no one has a firm idea what these future treatments could look like. Some say they will be genetic therapies added to people’s DNA; others expect it’s possible to discover chemical pills that do the job. One proponent of the technology, David Sinclair, who runs an aging-research lab at Harvard University, says it could allow people to live much longer than they do today. “I predict one day it will be normal to go to a doctor and get a prescription for a medicine that will take you back a decade,” Sinclair said at the same California event. “There is no reason we couldn’t live 200 years.”

It’s this type of claim that raises so much skepticism. Critics see ballooning hype, runaway egos, and science that’s on uncertain ground. But the doubters this year were drowned out by the sound of stampeding investors. In addition to Altos, whose $3 billion ranked as possibly the single largest startup fundraising drive in biotech history, the cryptocurrency billionaire Brian Armstrong, the cofounder of Coinbase, helped bring $105 million into his own reprogramming company, NewLimit, whose mission he says is “radical extension of human health span.” Retro Biosciences, which says it wants to “increase healthy human lifespan by 10 years,” raised $180 million.

These huge expenditures are being made despite the fact that scientists still disagree on the causes of aging. Indeed, there’s no real consensus on when in life aging even begins. Some say it starts at conception, while others think it’s at birth or after puberty. 

“There is no reason we couldn’t live 200 years.”

David Sinclair, Harvard University

But all the unknowns are part of what makes the reprogramming phenomenon so attractive. Klausner admits that the details of why reprogramming works remain a “complete mystery,” but that too helps explain the sudden rush to invest in the idea. If there is a fountain of youth in the genome, the first to locate it could reinvent medicine and revolutionize how we treat the myriad of diseases that plague our old age.  

Alchemy project

To get a reality check on Klausner’s lecture, I asked an embryologist and stem-cell specialist, Alfonso Martinez Arias, to watch a recording. Martinez, whose lab is at the Pompeu Fabra University, in Barcelona, wrote back that he had to hold his stomach while he watched, so grandiose were the claims. “He was evangelical about something which, at the moment, is interesting but very preliminary and [on] …….


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